Ribonucleotide reductase activity during amphibian development
نویسندگان
چکیده
منابع مشابه
New ribonucleotide reductase inhibitors with antineoplastic activity.
possible cancer chemotherapeutic agents. Howeven, pre himinary data indicate that these compounds are toxic and are not effective in humans (4, 14). In order to develop an effective chemothemapeutic agent for which the mode of action is inhibition of nibonucleotide meductase activity, a number of ahiphatic and aromatic hydroxamic acids and their corresponding amides and esters were synthesized ...
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suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
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MUCH evidence has accumulated to show that ammonia and urea excretion is characteristic of aquatic and amphibian life, and uric acid of terrestrial life [Needham, 1930; Delauney, 1935]. An ontogenetic sequence similar to the above has been shown to occur during the development of the chick [Needham, 1925]. During ontogenesis, at one stage 900 of the N excretion is present as NH3. On the other h...
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Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic, largely due to a lack of structural information about how the catalytic subunit (α(2)) and the r...
متن کاملRibonucleotide reductase activity in vitamin B12-deficient Euglena gracilis.
The ribonucleotide reductase activities in vitamin B12-sufficient and -deficient cells of Euglena gracilis were measured. We found that the cells progress into vitamin B12 deficiency the enzyme activity increases, reaching a maximum value of 20-fold in advanced deficiency. No signigicant differences in the activities were found to result as a consequence of different growth conditions. We propo...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
سال: 1975
ISSN: 0005-2787
DOI: 10.1016/0005-2787(75)90231-2